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KMID : 1216720120040020107
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Korean Journal of Gynecologic Endocrinology
2012 Volume.4 No. 2 p.107 ~ p.112
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Production of Interleukin(IL)-8, IL-18, and Soluble IL-18 Receptor by Whole Blood Cells from Women with Endometriosis
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Lee Hee-Jun
Kim Hoon
Park Gi-Yeon
Ku Seung-Yup
Kim Seok-Hyun
Choi Young-Min
Kim Jung-Gu
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Abstract
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Objectives: This study was investigated to evaluate the association between production of interleukin (IL)-8, IL-18, soluble IL-8 receptor (sIL-18R) from whole blood cells (WBCs) from women with and without endometriosis (ES)
Methods: The production of IL-8, IL-18, and sIL-18R by lipopolysaccharide-stimulated WBCs from women with ES (n=23) and normal women without ES (n=24) were determined by enzyme linked immunosorbent assay.
Results: No significant differences in the production of IL-8 by WBCs were noted between women with ES and normal control women. The production of IL-18 and sIL-18R by WBCs from women with ES was significantly (P<0.005) lower than those of normal control women respectively. These differences were not noted in early stage ES but in advanced stage ES.
Conclusion: The IL-18 and sIL-18R production by WBCs was significantly lower in women with ES than in normal controls. This result is related with decreased immune response in women with ES.
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KEYWORD
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Endometriosis, WBC, IL-8, IL-18, sIL-18R
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